Pioglitazone: an anti-diabetic compound with anti-aging properties

Baicalein, a novel anti-diabetic compound

Both in type 1 (T1D) and type 2 diabetes (T2D), the deterioration of glycemic control over time is primarily caused by an inadequate mass and progressive dysfunction of β-cells, leading to the impaired insulin secretion. Thus, the search for agents to protect -cell and enhance its function is important for diabetes treatment. Studies have reported that baicalein, a flavone originally isolated ...

Pioglitazone attenuates diabetic nephropathy through an anti-inflammatory mechanism in type 2 diabetic rats.

BACKGROUND Peroxisome proliferator-activated receptors (PPARs) are nuclear transcription factors that play a role in insulin sensitivity, lipid metabolism and inflammation. However, the effects of PPARgamma agonist on renal inflammation have not been fully examined in type 2 diabetic nephropathy. METHODS In the present study, we investigated the effect and molecular mechanism of the PPARgamma...

Anti-inflammatory effects of pioglitazone in diabetic kidney transplant recipients.

Poly herbal formulation with anti-elastase and anti-oxidant properties for skin anti-aging

BACKGROUND Skin forms an important part of human innate immune system. Wrinkles, thinning and roughening of skin are some of the symptoms that affect the skin as it ages. Reactive oxygen species induced oxidative stress plays a major role in skin aging by modulating the elastase enzyme level in the skin. Extrinsic factors that affect skin aging such as UV radiation can also cause malignant mela...

Anti-cancer compound from medicinal mushrooms

Various mushrooms have been used as folk medicine for long times, the higher Basidiomycetes have become a matter of great interest due to their diverse nutritional, medicinal, and pharmacological properties. 650 species and intraspecific taxa from 182 genera of higher Hetero- and Homo-basidiomycetes have been listed that contain biological active anti-tumor and immunostimulative polysaccharides...